A first half strike from Ireland international Brandon Miele and a second goal from Michael Richardson on 57 minutes was enough to secure the win for the home side, with many Development squad regulars currently involved in City under-18s FA Youth Cup run to the semi-finals.
Three points for the Magpies who now move level on points with the Canaries in Group 2.
It was a quiet start at Whitley Park as the home side started the brighter with Romain Amalfitano's strike just past the near the only chance of note from the early stages.
But the returning Ruddy could do little to stop Ireland youth international Brandon Miele from slotting home on 36 minutes as a neat one-two with Alex Gilliead saw him round the England international to put the home side in front.
City instantly responded however as Jamar Loza burst into the box only to see his powerful drive from ten yards parried by Magpies stopper Jak Alnwick.
The home side suffered a blow as the game headed to half-time as defender and Captain Curtis Good limped off following a collision with City midfielder Olu Durojaiye.
Half Time - Newcastle United Under-21s 1-0 Norwich City Under-21s
The home side were forced into another change at the break as Jonathyn Quinn replaced Rolando Aarons.
City started the second half brightly as Michael Clunan tested the hands of Alnwick early in the second half, soon after however the Magpies doubled their lead and secured the win as Michael Richardson made it two.
Recently returned from a loan spell at Gillingham he weaved past two challenges before placing the ball past City stopper John Ruddy
City had little response with Ewan McNeil's shot late on which curled just wide their only late effort of note.
Full-Time - Newcastle United Under-21s 2-0 Norwich City Under-21s
Newcastle United Under-21s: Jak Alnwick, Alex Nicholson, Yven Moyo, Steven Logan, Lubo Satka, Curtis Good (Kevin Mbabu 43), Rolando Aarons (Jonathyn Quinn 46), Brandon Miele, Alex Gilliead, Michael Richardson, Romain Amalfitano
Subs not used: Jonathan Mitchell, Alex Kitchen, Lee Desmond.
Norwich City Under-21s: John Ruddy
, Rian Carrroll, Ewan McNeil, Michael Clunan, Ramil Sheriff, Adel Gafaiti, Harvey Hodd, Olu Durojaiye, Jamar Loza, Harrison Heath (Dom St. Louis 68), Rhys Browne. Subs not used:
Michee Efete, Jed Steer, Jake Simpson, Nathan Fox