Hooper and van Wolfswinkel find the netFIVE Norwich City players featured for their loan clubs on Tuesday - with three competing in the same match.
MK Dons, battling to keep out of the bottom three in the Sky Bet Championship, welcomed Sheffield Wednesday, who are in touch with the play-off places under Carlos Carvalhal.
The game went in the underdogs' favour, however, as goals from Carl Baker and Nicky Maynard won it for MK Dons, despite substitute Gary Hooper's second half strike setting up a nervous finale for the hosts.
It was Hooper's first Owls goal since he moved there on loan in October - the former Celtic striker has, however, only started in two of his eight appearances.
Michael Turner played the full 90 minutes in defence for Wednesday, while Josh Murphy - who has clocked up 18 games for MK Dons so far this season - lasted 78 before being withdrawn.
Great to finally get off the mark for @swfc only 1 away from 200 career goals, shame about the result 2night. Another big game Sunday.— Gary Hooper (@HOOP588) December 15, 2015
Elsewhere in the second tier, Elliott Bennett's Bristol City were comfortably seen off by Derby County at the iPro Stadium.
Bennett, who came up against former City teammate and close friend Bradley Johnson, featured for 80 minutes but Tom Ince's hat-trick helped Derby to a 4-0 victory that kept their promotion ambitions on track.
Rotherham United pair Tony Andreu and Harry Toffolo were both unused substitutes as the Millers were beaten by Huddersfield Town.
Strikes from Mustapha Carayol and Ishmael Miller kept Rotherham rooted in the bottom three of the division, four points from safety.
Further afield, Ricky van Wolfswinkel bagged his first goals in Real Betis colours as his brace helped the Spanish side progress in the Copa del Rey.
Heading into their second leg with a 2-0 advantage over Sporting Gijon, Betis progressed after a thrilling 3-3 draw that saw Dutch international van Wolfswinkel score in each half.