Daniel Farke will be without Sam Byram, Onel Hernandez, Timm Klose and Christoph Zimmermann for Friday's visit of Leicester City.
Timm Klose (knee) is a long-term absentee but Farke thinks the Swiss defender isn't far away from a return to first-team action. His centre-back partner Christoph Zimmermann (hamstring) will miss a second game in succession.
Onel Hernandez (knee) has undergone surgery on a mensicus problems and Farke expects his winger to miss the next eight weeks.
There was particularly sad news on Sam Byram when Farke confirmed that his season is over after he picked up a hamstring injury in the defeat against Liverpool.