Norwich City duo Bali Mumba and Adam Idah will both miss the next ten weeks of action after suffering ligament injuries.
Mumba rolled his knee during training in the week and head coach Daniel Farke has labelled the injury an 'unlucky situation'.
Meanwhile, Idah started two of Republic of Ireland's matches during the international break but was forced to miss their third and final game against Bulgaria on Wednesday. It's been revealed the striker has damaged a ligament in his knee as well, meaning he will miss a similar amount of games to Mumba.
Furthermore, left-back Xavi Quintilla will also miss the trip to Middlesbrough on Saturday.
It wasn't all negative news though, with Farke revealing a number of players being available for the game who've had to miss previous matches.
"Grant Hanley and Max Aarons didn't travel to their national teams because of injury, but they are fine and available for the game," said the City boss at his pre-match press conference.
"In the last game [against Swansea], we played without Lukas Rupp, Ben Gibson and Todd Cantwell but their siutations are much-improved and they are available.
"Christoph Zimmermann came through the last game without any problems after being out for a while. He's available for tomorrow.
"Many lads arrived back late from their international teams after problems with flights and timings. It's been a bit complicated but there are no major issues with them."