Kenny McLean and Josh Sargent have both been ruled out for the rest of the season.
Dean Smith confirmed in his pre-West Ham United press conference on Friday morning that McLean has a fractured toe and will have to wear a protective boot.
Sargent has aggravated his ankle injury and won't be risked for the rest of the season.
They join Adam Idah and Andrew Omobamidele in looking to get ready for pre-season ahead of the 2022/23 campaign.
Christoph Zimmermann will miss the West Ham game as he is still out with a groin problem.